PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway

Abstract Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely human tumors. This study aimed to explore the molecular mechanisms of HCC. Using 150 formalin-fixed and paraffin-embedded samples 8 fresh samples, we found high expression HCC tumor tissues through Western blotting RT-PCR. Moreover, higher was poor prognosis patients. In vitro vivo experiments indicated overexpression promoted proliferation depressed apoptosis cells. High also increased autophagy underlying were examined by RNA-seq analysis series functional experiments. Results showed progression MAPK signaling pathway. Therefore, overexpressed HCC, autophagy, inhibited cells